The 40-room Hotel Colon Rambla is a mid-range property, primely located near downtown Santa Cruz. Its Rambla neighborhood is one of the nicest in Tenerife's capital, and a large park opposite breaks up the urban setting. Smart rooms are outfitted in streamlined palettes, and amenities include desks, minibars, and AC. Some have furnished balconies overlooking the outdoor pool, which is a pleasant spot but doesn't get much sun. A Mediterranean restaurant serves a buffet breakfast, and an all-day bar offers daytime coffees and snacks. Leisure and business travelers consider it one of Santa Cruz's better hotels, but note, certain amenities are at a fee. Hotel Taburiente has a rooftop pool and hot tub that gets more sun. 

The 64-room NH Tenerife is a mid-range hotel located right in the heart of Santa Cruz. Rooms have generic contemporary decor, free Wi-Fi, small flat-screen TVs, and minibars. The property is popular with business travelers, and features three well-equipped meeting rooms, and catering services for corporate events. The rooftop terrace is a pleasant spot for a quiet afternoon, and the restaurant serves a great breakfast buffet as well as Spanish cuisine for dinner. Small bites and room service area available throughout the day. The NH Tenerife is a solid option for visitors in town for work, but leisure guests may prefer the Hotel Taburiente, which has similarly styled rooms and a rooftop pool.